PF3D7_1366300

Genome location: Pf3D7_13_v3:2,638,584..2,653,705(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0036396	RNA N6-methyladenosine methyltransferase complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.64	0.34
Trophozoite	expressed	1.41	0.35
Schizont	expressed	1.00	0.49
Gametocyte	possibly expressed	1.44	0.34

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1366300

Resistome Missense Mutations: I130V

Resistome Compounds with Missense Mutations: AN13762, MMV084864, MMV1454442

Resistome # Samples with Disruptive Mutations: 16 (15 missense, 15 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.855 | MFS: -2.1 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533016

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	63	266	128	293
disruptive	243	780	371	859
missense	131	597	310	704

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	116	495	195	294
disruptive	424	1473	574	1183
missense	238	1147	463	844

PlasmoDB Total SNPs: 752

Non-coding: 232 | Synonymous: 256 | Nonsynonymous: 262 | Stop Codon: 2

Protein Information

Protein Length: 4136 | Molecular Weight (kDa): 494.685

UniProt ID(s): A0A5K1K933, Q9GVB5

PDB ID(s): None

Isoelectric Point: 5.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A