PF3D7_1366700

Genome location: Pf3D7_13_v3:2,665,864..2,668,733(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.37	0.81
Trophozoite	expressed	0.24	0.86
Schizont	possibly expressed	0.09	0.94
Gametocyte	expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1366700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.296 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID41

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532628

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	14	27
disruptive	14	73	36	88
missense	13	68	33	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	38	14	42
disruptive	35	161	47	112
missense	27	146	41	67

PlasmoDB Total SNPs: 222

Non-coding: 181 | Synonymous: 18 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 371 | Molecular Weight (kDa): 44.984

UniProt ID(s): Q8ID41

PDB ID(s): None

Isoelectric Point: 9.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A