Genome location: Pf3D7_13_v3:2,668,028..2,671,369(-)
Genome classification: Core
Product Description: phosphatidylserine synthase
SignalP Peptide: N/A
# Transmembrane Domains: 9
EC Numbers: 2.7.8.8 (CDP-diacylglycerol--serine O-phosphatidyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
| Function | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups |
| Function | GO:0005515 | protein binding |
| Process | GO:0006659 | phosphatidylserine biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1366800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -3.123 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5K9
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.8.8 | CDP-diacylglycerol-serine O-phosphatidyltransferase | Triton X-100 |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101724
Most Similar Human Ortholog: Q9BVG9
TM-align score: 0.73 | RMSD: 3.13
Seq Identity: 0.24 | Length: 293 / 357
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000156471 | phosphatidylserine synthase 1 |
| ENSG00000174915 | phosphatidylserine synthase 2 |
| ENSG00000282367 | phosphatidylserine synthase 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 24 | 13 | 22 |
| disruptive | 20 | 24 | 17 | 29 |
| missense | 20 | 24 | 17 | 29 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 47 | 14 | 28 |
| disruptive | 23 | 54 | 36 | 75 |
| missense | 23 | 49 | 34 | 54 |
PlasmoDB Total SNPs: 262
Non-coding: 231 | Synonymous: 9 | Nonsynonymous: 22 | Stop Codon: 0
Protein Length: 357 | Molecular Weight (kDa): 41.979
UniProt ID(s): C0H5K9
PDB ID(s): None
Isoelectric Point: 9.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004277 | Phosphatidyl serine synthase |
| PFam | PF03034 | Phosphatidyl serine synthase |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 35623558 | Defining ER-mitochondria contact dynamics in Plasmodium falciparum by targetingcomponent of phospholipid synthesis pathway, phosphatidylserine synthase (PfPSS). | Anwar MO, Islam MM, ..., Mohmmed A | 10.1016/j.mito.2022.05.005 |