Genome location: Pf3D7_13_v3:2,678,143..2,680,756(-)
Genome classification: Core
Product Description: suppressor of kinetochore protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0019005 | SCF ubiquitin ligase complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0097602 | cullin family protein binding |
| Process | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| Process | GO:0051382 | kinetochore assembly |
| Process | GO:0045116 | protein neddylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.07 | 0.96 |
| Trophozoite | expressed | 0.41 | 0.75 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | expressed | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1367000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.336 | MFS: -2.895 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1142900)
Modification: Tagged | RMgm-5333
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ID38
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100934
Most Similar Human Ortholog: P63208
TM-align score: 0.87 | RMSD: 2.09
Seq Identity: 0.46 | Length: 155 / 162
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000113558 | S-phase kinase associated protein 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 4 | 12 |
| disruptive | 0 | 6 | 2 | 9 |
| missense | 0 | 6 | 2 | 7 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 20 | 3 | 8 |
| disruptive | 1 | 17 | 15 | 37 |
| missense | 1 | 12 | 13 | 26 |
PlasmoDB Total SNPs: 195
Non-coding: 192 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 162 | Molecular Weight (kDa): 18.786
UniProt ID(s): Q8ID38
PDB ID(s): None
Isoelectric Point: 4.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001232 | S-phase kinase-associated protein 1-like |
| InterPro | IPR011333 | SKP1/BTB/POZ domain superfamily |
| InterPro | IPR016072 | SKP1 component, dimerisation |
| InterPro | IPR016073 | SKP1 component, POZ domain |
| InterPro | IPR016897 | S-phase kinase-associated protein 1 |
| InterPro | IPR036296 | SKP1-like, dimerisation domain superfamily |
| PFam | PF01466 | SKP1 component, dimerisation |
| PFam | PF03931 | SKP1 component, POZ domain |
| Superfamily | SSF54695 | SKP1/BTB/POZ domain superfamily |
| Superfamily | SSF81382 | SKP1-like, dimerisation domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 38416790 | Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, andCRL4 is critical for cell division and membrane integrity | Rizvi Z, Reddy GS, ..., Sijwali PS | 10.1371/journal.ppat.1012045 |
| 38187549 | Toxoplasma gondii F-Box Protein L2 Silences Feline-Restricted Genes Necessary forSexual Commitment | Baptista CG, Hosking S, ..., Blader IJ | 10.1101/2023.12.18.572150 |