PF3D7_1367200

Genome location: Pf3D7_13_v3:2,683,581..2,684,967(+)

Genome classification: Core

Function and Localization

Product Description: CLAMP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.50	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1367200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -0.722 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1143100)

Relative Growth Rate: 1.06 ± 0.15
Confidence: 5.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1143100)

Modification: Disrupted | RMgm-3150

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5L0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106153

Most Similar Human Ortholog: F5H7A8

TM-align score: 0.64 | RMSD: 1.66

Seq Identity: 0.04 | Length: 55 / 367

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000196118	coiled-coil domain containing 189

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	25	17	24
disruptive	6	61	32	80
missense	6	60	32	74

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	49	13	27
disruptive	20	118	58	80
missense	17	106	51	71

PlasmoDB Total SNPs: 54

Non-coding: 34 | Synonymous: 12 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 367 | Molecular Weight (kDa): 44.642

UniProt ID(s): C0H5L0

PDB ID(s): None

Isoelectric Point: 9.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR032727	Flagellar C1a complex subunit C1a-32
PFam	PF14769	Flagellar C1a complex subunit C1a-32
Superfamily	N/A	N/A