PF3D7_1367300

Genome location: Pf3D7_13_v3:2,685,059..2,686,331(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MYRVIFYVATFVLILNFVLRIPQICSC

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.96
Trophozoite	not expressed	0.06	0.97
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1367300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.976 | MFS: -2.529 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1143200)

Relative Growth Rate: 1.01 ± 0.12
Confidence: 5.64

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1143200)

Modification: Disrupted | RMgm-3151

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID35

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110052

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	22	6	26
disruptive	11	37	28	48
missense	11	37	26	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	32	14	26
disruptive	18	76	43	66
missense	15	70	37	53

PlasmoDB Total SNPs: 87

Non-coding: 58 | Synonymous: 23 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 335 | Molecular Weight (kDa): 40.367

UniProt ID(s): Q8ID35

PDB ID(s): None

Isoelectric Point: 8.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A