PF3D7_1367400

Genome location: Pf3D7_13_v3:2,687,168..2,691,319(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030686	90S preribosome
Component	GO:0005730	nucleolus
Component	GO:0030688	preribosome, small subunit precursor
Function	GO:0003723	RNA binding
Process	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of
Process	GO:0000056

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.89	0.59
Trophozoite	expressed	0.47	0.75
Schizont	not expressed	0.13	0.92
Gametocyte	possibly expressed	0.40	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1367400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.991 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID34

"Best" AlphaFill ligand hit: UTP (uridine 5'-triphosphate, Local RMSD=4.49) with 7X4P (Global RMSD=17.29)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533107

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	79	34	74
disruptive	34	163	81	198
missense	24	154	77	177

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	28	138	38	78
disruptive	68	328	145	306
missense	51	287	120	228

PlasmoDB Total SNPs: 152

Non-coding: 71 | Synonymous: 42 | Nonsynonymous: 37 | Stop Codon: 2

Protein Information

Protein Length: 1046 | Molecular Weight (kDa): 125.2

UniProt ID(s): Q8ID34

PDB ID(s): None

Isoelectric Point: 8.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR040000	Nucleolar protein 9
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
20335165	Transmembrane segment 11 appears to line the purine permeation pathway of thePlasmodium falciparum equilibrative nucleoside transporter 1 (PfENT1).	Riegelhaupt PM, Frame IJ, Akabas MH	10.1074/jbc.M110.115758