PF3D7_1367600

Genome location: Pf3D7_13_v3:2,693,485..2,695,219(-)

Genome classification: Core

Function and Localization

Product Description: ribosome biogenesis protein MRT4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Component	GO:0005634	nucleus
Component	GO:0030687	preribosome, large subunit precursor
Process	GO:0000956	nuclear-transcribed mRNA catabolic process
Process	GO:0006364	rRNA processing
Process	GO:0000027	ribosomal large subunit assembly
Process	GO:0042273	ribosomal large subunit biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.30	0.85
Trophozoite	possibly expressed	0.22	0.87
Schizont	not expressed	0.04	0.98
Gametocyte	possibly expressed	0.18	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1367600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.202 | MFS: -3.374 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID32

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102229

Most Similar Human Ortholog: Q9UKD2

TM-align score: 0.84 | RMSD: 2.04

Seq Identity: 0.23 | Length: 206 / 222

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000053372	MRT4 homolog, ribosome maturation factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	10	17
disruptive	3	15	20	22
missense	3	15	20	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	25	16	20
disruptive	6	44	25	49
missense	4	36	22	36

PlasmoDB Total SNPs: 89

Non-coding: 81 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 222 | Molecular Weight (kDa): 25.828

UniProt ID(s): Q8ID32

PDB ID(s): None

Isoelectric Point: 10.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001790	Ribosomal protein L10P
InterPro	IPR040637	60S ribosomal protein L10P, insertion domain
InterPro	IPR043141	Ribosomal protein L10-like domain superfamily
PFam	PF00466	Ribosomal protein L10P
PFam	PF17777	60S ribosomal protein L10P, insertion domain
Superfamily	SSF160369	Ribosomal protein L10-like domain superfamily