PF3D7_1367800 (PSOP2)

Genome location: Pf3D7_13_v3:2,701,228..2,704,776(+)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MKLNTLISFFSFVCLFFRVLSC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1367800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.335 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1143700)

Modification: Disrupted | RMgm-3154

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID30

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
P37840	Alpha-synuclein		OrthoMCL BLAST	US9085549, 52US9085549, 53US9085549, 54US9085549, 55...

Orthology Information

Ortholog Group (OrthoMCL): OG6_111908

No human ortholog(s)

Protein Information

Protein Length: 1182 | Molecular Weight (kDa): 135.834

UniProt ID(s): Q8ID30

PDB ID(s): None

Isoelectric Point: 4.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	52	33	65
disruptive	85	215	110	243
missense	46	147	83	169

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	99	35	80
disruptive	142	374	135	268
missense	75	263	102	170

PlasmoDB Total SNPs: 294

Non-coding: 0 | Synonymous: 156 | Nonsynonymous: 138 | Stop Codon: 0