PF3D7_1367900

Genome location: Pf3D7_13_v3:2,706,499..2,708,442(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1367900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.648 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1143800)

Modification: Disrupted | RMgm-1295

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5L1

"Best" AlphaFill ligand hit: OPE (phosphoric acid mono-(2-amino-ethyl) ester, Local RMSD=0.37) with 3UJB (Global RMSD=26.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533602

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	25	21	40
disruptive	22	100	58	129
missense	20	92	53	114

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	51	28	43
disruptive	41	205	88	207
missense	33	176	76	142

PlasmoDB Total SNPs: 51

Non-coding: 0 | Synonymous: 32 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 647 | Molecular Weight (kDa): 77.874

UniProt ID(s): C0H5L1

PDB ID(s): None

Isoelectric Point: 6.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A