Genome location: Pf3D7_13_v3:2,713,313..2,717,072(-)
Genome classification: Core
Product Description: ABC transporter E family member 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005524 | ATP binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0005506 | iron ion binding |
| Function | GO:0043024 | ribosomal small subunit binding |
| Process | GO:0000054 | ribosomal subunit export from nucleus |
| Process | GO:0006413 | translational initiation |
| Process | GO:0006415 | translational termination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | possibly expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1368200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.127 | MFS: -3.138 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1144100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I6Z4
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.05) with 6GKD (Global RMSD=5.33)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101314
Most Similar Human Ortholog: P61221
TM-align score: 0.98 | RMSD: 1.28
Seq Identity: 0.62 | Length: 599 / 619
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164163 | ATP binding cassette subfamily E member 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 44 | 28 | 36 |
| disruptive | 3 | 6 | 5 | 40 |
| missense | 3 | 6 | 4 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 95 | 26 | 29 |
| disruptive | 9 | 31 | 34 | 79 |
| missense | 7 | 16 | 28 | 65 |
PlasmoDB Total SNPs: 192
Non-coding: 168 | Synonymous: 19 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 619 | Molecular Weight (kDa): 70.27
UniProt ID(s): Q8I6Z4
PDB ID(s): None
Isoelectric Point: 9.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR007209 | RNase L inhibitor RLI, possible metal-binding domain |
| InterPro | IPR013283 | RLI1 |
| InterPro | IPR017871 | ABC transporter, conserved site |
| InterPro | IPR017896 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| InterPro | IPR017900 | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR034348 | RLI, domain 1 |
| PFam | PF00005 | ABC transporter-like |
| PFam | PF00037 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| PFam | PF04068 | RNase L inhibitor RLI, possible metal-binding domain |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF54862 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 36401432 | A pan-cancer analysis of the oncogenic role of ATP binding cassette subfamily Emember 1 (ABCE1) in human tumors: An observational study | Yu J, Ma H, ..., Dai Z | 10.1097/MD.0000000000031849 |
| 35792803 | Human ABCE1 exhibits temperature-dependent heterologous co-functionality inS. cerevisiae | Wada M, Ito K | 10.1002/2211-5463.13463 |
| 37247928 | Casein Kinase 2alpha Augments Oxaliplatin Resistance in Colorectal Cancer Cells by Increasing ABCE1 Expression | Yun CW, Lee JH, Lee SH | 10.21873/anticanres.16419 |
| 37738929 | ABCE1 selectively promotes HIF-1alpha transactivation of angiogenic gene expression | Sun L, Ding X, Kang YJ | 10.1016/j.jtemb.2023.127307 |
| 38198768 | Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosomerecycling factors Tma20/22 in nonsense mediated decay | Pacheco M, D'Orazio KN, ..., Green R | 10.1093/g3journal/jkad295 |
| 35403616 | [Role of Proteins Interacting with the eRF1 and eRF3 Release Factors in theRegulation of Translation and Prionization] | Zhouravleva GA, Bondarev SA, Zemlyanko OM, Moskalenko SE | 10.31857/S002689842201013X |