PF3D7_1368400

Genome location: Pf3D7_13_v3:2,718,413..2,721,928(-)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein L1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.28	0.86
Trophozoite	possibly expressed	0.61	0.65
Schizont	possibly expressed	0.47	0.71
Gametocyte	expressed	0.53	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1368400

Resistome Missense Mutations: F202Y

Resistome Compounds with Missense Mutations: Artemisinin

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.907 | MFS: -1.192 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1144300)

Relative Growth Rate: 0.55 ± 0.13
Confidence: 5.40

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1144300)

Modification: Disrupted | RMgm-3157

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID26

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102551

Most Similar Human Ortholog: I3L3C4

TM-align score: 0.71 | RMSD: 2.91

Seq Identity: 0.16 | Length: 146 / 320

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000171490	ribosomal L1 domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	21	7	35
disruptive	4	23	10	43
missense	1	23	9	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	42	12	27
disruptive	11	53	32	67
missense	6	41	26	49

PlasmoDB Total SNPs: 307

Non-coding: 287 | Synonymous: 6 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 320 | Molecular Weight (kDa): 38.265

UniProt ID(s): Q8ID26

PDB ID(s): None

Isoelectric Point: 10.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR023674	Ribosomal protein L1-like
InterPro	IPR028364	Ribosomal protein L1/ribosomal biogenesis protein
PFam	PF00687	Ribosomal protein L1/ribosomal biogenesis protein
Superfamily	SSF56808	Ribosomal protein L1-like