PF3D7_1368500

Genome location: Pf3D7_13_v3:2,722,470..2,725,470(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.13	0.91
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.26	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1368500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.068 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1144400)

Relative Growth Rate: 0.16 ± 0.25
Confidence: 4.16

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K937

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532965

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	50	25	59
disruptive	14	105	53	108
missense	13	103	52	104

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	86	43	60
disruptive	31	229	93	198
missense	27	198	82	153

PlasmoDB Total SNPs: 71

Non-coding: 22 | Synonymous: 26 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 830 | Molecular Weight (kDa): 100.114

UniProt ID(s): A0A5K1K937

PDB ID(s): None

Isoelectric Point: 9.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A