PF3D7_1368700

Genome location: Pf3D7_13_v3:2,727,274..2,729,996(-)

Genome classification: Core

Function and Localization

Product Description: mitochondrial carrier protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005743	mitochondrial inner membrane
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	possibly expressed	0.63	0.65
Schizont	expressed	0.33	0.79
Gametocyte	not expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1368700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.209 | MFS: -2.781 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID23

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126785

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	31	18	39
disruptive	25	88	40	96
missense	16	76	32	83

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	66	33	44
disruptive	42	194	70	167
missense	23	152	57	121

PlasmoDB Total SNPs: 149

Non-coding: 88 | Synonymous: 36 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 576 | Molecular Weight (kDa): 67.86

UniProt ID(s): Q8ID23

PDB ID(s): None

Isoelectric Point: 10.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002067	Mitochondrial carrier protein
InterPro	IPR018108	Mitochondrial substrate/solute carrier
InterPro	IPR023395	Mitochondrial carrier domain superfamily
PFam	PF00153	Mitochondrial substrate/solute carrier
Superfamily	SSF103506	Mitochondrial carrier domain superfamily