PF3D7_1368900

Genome location: Pf3D7_13_v3:2,738,083..2,741,740(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.03	0.99
Trophozoite	expressed	0.09	0.94
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1368900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.67 | MFS: -2.452 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1144800)

Relative Growth Rate: 0.89 ± 0.14
Confidence: 5.34

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1144800)

Modification: Disrupted | RMgm-3160

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9A4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103038

Most Similar Human Ortholog: K7EIJ0

TM-align score: 0.64 | RMSD: 2.17

Seq Identity: 0.22 | Length: 120 / 450

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000132471	WW domain binding protein 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	31	21	33
disruptive	18	60	34	81
missense	10	46	31	66

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	58	22	32
disruptive	31	113	54	127
missense	21	92	47	83

PlasmoDB Total SNPs: 201

Non-coding: 151 | Synonymous: 34 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 450 | Molecular Weight (kDa): 52.012

UniProt ID(s): A0A5K1K9A4

PDB ID(s): None

Isoelectric Point: 7.56

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF50729	N/A