PF3D7_1369100

Genome location: Pf3D7_13_v3:2,746,174..2,748,732(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.51	0.71
Schizont	not expressed	0.12	0.92
Gametocyte	not expressed	0.97	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1369100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.056 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9B9

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.79) with 3A4L (Global RMSD=30.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533130

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	32	21	37
disruptive	36	151	60	119
missense	16	114	51	99

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	67	26	29
disruptive	81	252	80	148
missense	38	195	61	91

PlasmoDB Total SNPs: 133

Non-coding: 49 | Synonymous: 54 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 521 | Molecular Weight (kDa): 62.477

UniProt ID(s): A0A5K1K9B9

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A