PF3D7_1369200

Genome location: Pf3D7_13_v3:2,748,967..2,756,484(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.59	0.73
Trophozoite	possibly expressed	0.95	0.51
Schizont	possibly expressed	0.42	0.76
Gametocyte	expressed	0.62	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1369200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.83 | MFS: -2.983 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8M3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533223

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	143	77	157
disruptive	121	492	255	490
missense	88	437	233	427

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	49	268	93	153
disruptive	211	944	331	564
missense	150	830	274	399

PlasmoDB Total SNPs: 350

Non-coding: 73 | Synonymous: 142 | Nonsynonymous: 134 | Stop Codon: 1

Protein Information

Protein Length: 2170 | Molecular Weight (kDa): 259.086

UniProt ID(s): A0A5K1K8M3

PDB ID(s): None

Isoelectric Point: 9.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF141571	N/A