PF3D7_1369300

Genome location: Pf3D7_13_v3:2,755,662..2,758,407(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.03	0.98
Gametocyte	expressed	1.27	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1369300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 6 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.157 | MFS: -3.003 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID17

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532388

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	25	13	35
disruptive	11	106	44	90
missense	10	102	41	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	58	25	25
disruptive	34	188	58	110
missense	25	170	48	88

PlasmoDB Total SNPs: 155

Non-coding: 104 | Synonymous: 32 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 420 | Molecular Weight (kDa): 49.866

UniProt ID(s): Q8ID17

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A