PF3D7_1369400

Genome location: Pf3D7_13_v3:2,759,048..2,768,913(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.20	0.90
Trophozoite	expressed	0.66	0.63
Schizont	possibly expressed	0.28	0.83
Gametocyte	not expressed	0.65	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1369400

Resistome Missense Mutations: R198I

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.136 | MFS: -3.177 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1145300)

Relative Growth Rate: 0.10 ± nan
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532573

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	25	180	77	191
disruptive	116	557	301	584
missense	102	534	287	522

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	52	314	129	191
disruptive	205	1101	414	853
missense	180	977	366	608

PlasmoDB Total SNPs: 359

Non-coding: 50 | Synonymous: 142 | Nonsynonymous: 166 | Stop Codon: 1

Protein Information

Protein Length: 2868 | Molecular Weight (kDa): 346.811

UniProt ID(s): C0H5L6

PDB ID(s): None

Isoelectric Point: 7.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A