PF3D7_1369500

Genome location: Pf3D7_13_v3:2,769,414..2,773,904(+)

Genome classification: Core

Function and Localization

Product Description: nuclear cap-binding protein subunit 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0098808	mRNA cap binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.56	0.73
Trophozoite	expressed	0.67	0.62
Schizont	expressed	0.11	0.92
Gametocyte	possibly expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1369500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.925 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1145500)

Modification: Disrupted | RMgm-3163

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8X7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532920

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	76	29	52
disruptive	28	88	58	140
missense	19	80	50	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	108	45	52
disruptive	52	203	95	211
missense	35	163	79	156

PlasmoDB Total SNPs: 212

Non-coding: 106 | Synonymous: 65 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 1106 | Molecular Weight (kDa): 131.374

UniProt ID(s): A0A5K1K8X7

PDB ID(s): None

Isoelectric Point: 4.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR027159	Nuclear cap-binding protein subunit 1
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold