PF3D7_1369600

Genome location: Pf3D7_13_v3:2,773,725..2,776,948(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKIILKITLLFSVINNLSIC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.29	0.86
Trophozoite	expressed	0.86	0.55
Schizont	expressed	0.24	0.85
Gametocyte	possibly expressed	0.73	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1369600

Resistome Missense Mutations: N332Y

Resistome Compounds with Missense Mutations: OSM-S-106

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.886 | MFS: -2.985 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1145600)

Relative Growth Rate: 0.10 ± 0.12
Confidence: 5.65

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K942

"Best" AlphaFill ligand hit: 5AD (5'-deoxyadenosine, Local RMSD=0.07) with 5Z79 (Global RMSD=22.94)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533201

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	36	21	46
disruptive	27	121	48	138
missense	21	109	43	121

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	70	33	47
disruptive	52	203	92	188
missense	39	173	79	127

PlasmoDB Total SNPs: 143

Non-coding: 34 | Synonymous: 68 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 897 | Molecular Weight (kDa): 107.897

UniProt ID(s): A0A5K1K942

PDB ID(s): None

Isoelectric Point: 6.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A