Genome location: Pf3D7_13_v3:2,777,488..2,779,407(-)
Genome classification: Core
Product Description: U2 small nuclear ribonucleoprotein A', putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005681 | spliceosomal complex |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.11 | 0.94 |
| Trophozoite | no data | 0.18 | 0.88 |
| Schizont | no data | 0.03 | 0.98 |
| Gametocyte | no data | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1369700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.77 | MFS: -3.737 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5L8
"Best" AlphaFill ligand hit: 15P (peg 1500, Local RMSD=1.25) with 6F4J (Global RMSD=0.91)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102567
Most Similar Human Ortholog: H0YKK0
TM-align score: 0.96 | RMSD: 0.99
Seq Identity: 0.48 | Length: 153 / 175
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000131876 | small nuclear ribonucleoprotein polypeptide A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 9 | 5 | 19 |
| disruptive | 1 | 9 | 4 | 22 |
| missense | 1 | 9 | 4 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 16 | 2 | 19 |
| disruptive | 1 | 22 | 18 | 38 |
| missense | 1 | 19 | 11 | 32 |
PlasmoDB Total SNPs: 110
Non-coding: 100 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 175 | Molecular Weight (kDa): 20.418
UniProt ID(s): C0H5L8
PDB ID(s): None
Isoelectric Point: 4.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003591 | Leucine-rich repeat, typical subtype |
| PFam | PF14580 | N/A |
| Superfamily | SSF52058 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 29563929 | Classification and Biomarker Genes Selection for Cancer Gene Expression Data Using Random Forest | Ram M, Najafi A, Shakeri MT | https://pubmed.ncbi.nlm.nih.gov/29563929/ |
| 31919495 | Mimicking of splicing-related retinitis pigmentosa mutations in C. elegans allowdrug screens and identification of disease modifiers | Kukhtar D, Rubio-Pena K, Serrat X, Ceron J | 10.1093/hmg/ddz315 |