About Gene List

PF3D7_1370300 (MAHRP1)

Genome location: Pf3D7_13_v3:2,786,609..2,789,345(+)

Genome classification: Core

Function and Localization

Product Description: membrane associated histidine-rich protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:1903561 extracellular vesicle
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 2.15 0.30
Trophozoite no data 0.53 0.77
Schizont no data 0.35 0.82
Gametocyte no data 0.35 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1370300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.964 | MFS: -2.237 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1145900)

Modification: Disrupted | RMgm-3165

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5L9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533021

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 3 15
disruptive 25 19 6 41
missense 13 4 3 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 12 11 14
disruptive 33 44 27 73
missense 14 13 14 46

PlasmoDB Total SNPs: 87

Non-coding: 49 | Synonymous: 21 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 249 | Molecular Weight (kDa): 28.949

UniProt ID(s): C0H5L9, Q6V0W7, Q6V0W8, Q6V0W9, Q6V0X0, Q6V0X1, Q6V0X3, Q9NNV9

PDB ID(s): None

Isoelectric Point: 6.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12815049 MAHRP-1, a novel Plasmodium falciparum histidine-rich protein, bindsferriprotoporphyrin IX and localizes to the Maurer's clefts. Spycher C, Klonis N, ..., Beck HP 10.1074/jbc.M305851200
28944300 Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. Abdi A, Yu L, ..., Rayner J 10.12688/wellcomeopenres.11910.2
31476617 A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes. Takano R, Kozuka-Hata H, ..., Kato K 10.1016/j.isci.2019.07.035
32184257 Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking McHugh E, Carmo OMS, ..., Dixon MWA 10.1128/mBio.03320-19
27225796 The machinery underlying malaria parasite virulence is conserved between rodentand human malaria parasites De Niz M, Ullrich AK, ..., Spielmann T 10.1038/ncomms11659
16705161 Genesis of and trafficking to the Maurer's clefts of Plasmodiumfalciparum-infected erythrocytes Spycher C, Rug M, ..., Tilley L 10.1128/MCB.00095-06
18410498 The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to thesurface of Plasmodium falciparum-infected erythrocytes Spycher C, Rug M, ..., Beck HP 10.1111/j.1365-2958.2008.06235.x
19166814 A Maurer's cleft-associated Plasmodium falciparum membrane-associatedhistidine-rich protein peptide specifically interacts with the erythrocytemembrane Garcia J, Curtidor H, ..., Patarroyo ME 10.1016/j.bbrc.2009.01.050