PF3D7_1371700 (FIKK13)

Genome location: Pf3D7_13_v3:2,821,078..2,824,446(+)

Genome classification: Core

Function and Localization

Product Description: serine/threonine protein kinase, FIKK family

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Function	GO:0004674	protein serine/threonine kinase activity
Process	GO:0035556	intracellular signal transduction
Process	GO:0044003	modulation by symbiont of host process
Process	GO:0006468	protein phosphorylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.06	0.97
Trophozoite	no data	0.40	0.77
Schizont	no data	0.26	0.85
Gametocyte	no data	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1371700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.71 | #Insertions: 3

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1225000)

Relative Growth Rate: 0.30 ± 0.11
Confidence: 5.77

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZWL4

"Best" AlphaFill ligand hit: TAK (dorsomorphin, Local RMSD=1.33) with 6GVX (Global RMSD=5.97)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111291

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 125

Non-coding: 88 | Synonymous: 27 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 561 | Molecular Weight (kDa): 67.228

UniProt ID(s): A0A143ZWL4

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000719	Protein kinase domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR011009	Protein kinase-like domain superfamily
PFam	PF00069	Protein kinase domain
Superfamily	SSF56112	Protein kinase-like domain superfamily