PF3D7_1372100 (GEXP04)

Genome location: Pf3D7_13_v3:2,835,756..2,839,580(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.05	0.98
Trophozoite	no data	0.07	0.97
Schizont	no data	0.03	0.99
Gametocyte	no data	0.76	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1372100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.007 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5M8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131849

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 201

Non-coding: 143 | Synonymous: 19 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 609 | Molecular Weight (kDa): 73.021

UniProt ID(s): C0H5M8

PDB ID(s): None

Isoelectric Point: 4.85

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A