Genome location: Pf3D7_13_v3:2,840,236..2,842,840(-)
Genome classification: Core
Product Description: histidine-rich protein III
SignalP Peptide: MVSFSKNKIL
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0020020 | food vacuole |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 1.01 | 0.66 |
| Trophozoite | no data | 0.25 | 0.89 |
| Schizont | no data | 0.08 | 0.96 |
| Gametocyte | no data | 0.06 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1372200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.811 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5M9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P05227 | Histidine-rich protein PFHRP-II | Plasmodium falciparum | OrthoMCL BLAST | CHEMBL152635CHEMBL2111198CHEMBL152052CHEMBL346177... |
Protein Length: 275 | Molecular Weight (kDa): 29.531
UniProt ID(s): C0H5M9
PDB ID(s): None
Isoelectric Point: 6.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008779 | Plasmodium histidine-rich |
| PFam | PF05403 | Plasmodium histidine-rich |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 221
Non-coding: 99 | Synonymous: 82 | Nonsynonymous: 40 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 8539625 | Plasmodium hemozoin formation mediated by histidine-rich proteins. | Sullivan DJ Jr, Gluzman IY, Goldberg DE | 10.1126/science.271.5246.219 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 33926477 | HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regionswith Plasmodium falciparum hrp2 gene deletions. | Kong A, Wilson SA, ..., Aidoo M | 10.1186/s12936-021-03739-6 |
| 34702923 | Epidemiology of mutant Plasmodium falciparum parasites lacking histidine-richprotein 2/3 genes in Eritrea 2 years after switching from HRP2-based RDTs. | Mihreteab S, Anderson K, ..., Cheng Q | 10.1038/s41598-021-00714-8 |
| 35114396 | Pfhrp2/3 gene deletion and genetic variation in PfHRP2-based RDTs with P.falciparum positive samples from India and its implication on malaria control. | Kumari MS, Sharma S, ..., Anvikar AR | 10.1016/j.meegid.2022.105232 |
| 37754284 | Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea. | Mihreteab S, Platon L, ..., Menard D | 10.1056/NEJMoa2210956 |
| 1983036 | Polymorphism of the TRAP gene of Plasmodium falciparum | Robson KJ, Hall JR, ..., Wellems TE | 10.1098/rspb.1990.0126 |
| 3320887 | Comparative analysis of the Plasmodium falciparum histidine-rich proteins HRP-I,HRP-II and HRP-III in malaria parasites of diverse origin | Rock EP, Marsh K, ..., Howard RJ | 10.1017/s0031182000057681 |
| 2884039 | A histidine-rich protein gene marks a linkage group favored strongly in a geneticcross of Plasmodium falciparum | Wellems TE, Walliker D, ..., McCutchan TF | 10.1016/0092-8674(87)90539-3 |
| 10838219 | Plasmodium falciparum: red blood cell binding studies of peptides derived fromhistidine-rich KAHRP-I, HRP-II and HRP-III proteins | Lopez R, Urquiza M, ..., Patarroyo ME | 10.1016/s0001-706x(00)00071-1 |
| 10411941 | A set of independent selectable markers for transfection of the human malariaparasite Plasmodium falciparum | Mamoun CB, Gluzman IY, ..., Goldberg DE | 10.1073/pnas.96.15.8716 |