About Gene List

PF3D7_1372300

Genome location: Pf3D7_13_v3:2,843,157..2,847,557(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTa-like)

SignalP Peptide: MKNVYFNRSLKFLCLTVCLILTIYS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell
Component GO:0030430 host cell cytoplasm
Component GO:0033644 host cell membrane
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.61 0.71
Trophozoite no data 0.09 0.95
Schizont no data 0.06 0.96
Gametocyte no data 0.04 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1372300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.771 | MFS: -2.717 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZR8

"Best" AlphaFill ligand hit: GRG (geranylgeranyl diphosphate, Local RMSD=0.04) with 3DRA (Global RMSD=18.21)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 171

Non-coding: 130 | Synonymous: 25 | Nonsynonymous: 10 | Stop Codon: 6

Protein Information

Protein Length: 206 | Molecular Weight (kDa): 24.218

UniProt ID(s): A0A143ZZR8

PDB ID(s): 7D2W

Isoelectric Point: 9.39

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12