PF3D7_1372600 (RIF)

Genome location: Pf3D7_13_v3:2,856,586..2,858,026(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: rifin

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.01	0.99
Schizont	no data	0.00	1.00
Gametocyte	no data	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1372600

Resistome Missense Mutations: S185R

Resistome Compounds with Missense Mutations: Sapanisertib

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.899 | MFS: -2.114 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5N2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 296

Non-coding: 136 | Synonymous: 61 | Nonsynonymous: 97 | Stop Codon: 2

Protein Information

Protein Length: 272 | Molecular Weight (kDa): 30.639

UniProt ID(s): C0H5N2

PDB ID(s): None

Isoelectric Point: 6.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006373	Variant surface antigen Rifin
PFam	PF02009	Variant surface antigen Rifin
Superfamily	N/A	N/A