PF3D7_1373500 (VAR)

Genome location: Pf3D7_13_v3:2,884,786..2,892,340(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1373500

Resistome Missense Mutations: K343N, L346I, K1289N, V1572I, K1937N, T1978S, N2017D, L2057I, E2091K, H2184Q, A2186V, T2191S

Resistome Compounds with Missense Mutations: AN13762, AN13956, GNF-Pf-5611, Halofuginone, Lopinavir

Resistome # Samples with Disruptive Mutations: 13 (12 missense, 4 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ID12

"Best" AlphaFill ligand hit: ETE (2-{2-[2-2-(methoxy-ethoxy)-ethoxy]-ethoxy}-ethanol, Local RMSD=0.13) with 6HSA (Global RMSD=12.54)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 2653

Non-coding: 422 | Synonymous: 672 | Nonsynonymous: 1552 | Stop Codon: 7

Protein Information

Protein Length: 2223 | Molecular Weight (kDa): 252.41

UniProt ID(s): A0A5P1A0P0, A0A5P1A188, A0A5P1A197, A0A5P1A1K6, A0A5P1A1Z7, A3R6U5, A3R6U7, Q8ID12

PDB ID(s): None

Isoelectric Point: 5.07

Protein Domain Annotations: