About Gene List

PF3D7_1401000 (GBPH)

Genome location: Pf3D7_14_v3:34,693..35,773(-)

Genome classification: Core

Function and Localization

Product Description: GBPH protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.01 1.00
Trophozoite expressed 0.03 0.98
Schizont expressed 0.00 1.00
Gametocyte not expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1401000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.446 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM78

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156154

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 158

Non-coding: 16 | Synonymous: 68 | Nonsynonymous: 73 | Stop Codon: 1

Protein Information

Protein Length: 307 | Molecular Weight (kDa): 34.627

UniProt ID(s): Q8IM78

PDB ID(s): None

Isoelectric Point: 6.1

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003681 Glycophorin-binding protein
PFam PF02526 Glycophorin-binding protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12
1775169 A Plasmodium falciparum blood stage antigen highly homologous to the glycophorinbinding protein GBP Nolte D, Hundt E, Langsley G, Knapp B 10.1016/0166-6851(91)90069-i