About Gene List

PF3D7_1401200

Genome location: Pf3D7_14_v3:46,160..48,541(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: MFPSYIRKFSFTLLLCIIALS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell
Component GO:0044538 host cell periphery
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.23 0.90
Trophozoite expressed 1.46 0.36
Schizont expressed 0.17 0.90
Gametocyte not expressed 0.08 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1401200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.225 | MFS: -2.873 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM76

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533152

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 1
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 1 0 0
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 88

Non-coding: 30 | Synonymous: 7 | Nonsynonymous: 51 | Stop Codon: 0

Protein Information

Protein Length: 264 | Molecular Weight (kDa): 31.285

UniProt ID(s): Q8IM76

PDB ID(s): None

Isoelectric Point: 10.35

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
27777305 Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. Davies HM, Thalassinos K, Osborne AR 10.1074/jbc.M116.761213
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332