Product Description: epoxide hydrolase 2
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 3.4.11.5 (Prolyl aminopeptidase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0044538 | host cell periphery |
| Function | GO:0004177 | aminopeptidase activity |
| Function | GO:0004301 | epoxide hydrolase activity |
| Function | GO:0016787 | hydrolase activity |
| Function | GO:0030507 | spectrin binding |
| Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.35 | 0.83 |
| Trophozoite | expressed | 0.18 | 0.91 |
| Schizont | expressed | 0.07 | 0.96 |
| Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1401300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.891 | MFS: -3.073 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0704400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM75
"Best" AlphaFill ligand hit: PPI (propanoic acid, Local RMSD=1.44) with 1A8S (Global RMSD=2.98)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.11.5 | prolyl aminopeptidase | DTTDFPEDTAPCMBPMSFTLCKTPCKDCICHgCl2ZnCl2CuCl2PbCl2... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 22 | 14 | 24 |
| disruptive | 15 | 27 | 14 | 54 |
| missense | 15 | 25 | 12 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 47 | 14 | 23 |
| disruptive | 28 | 58 | 38 | 81 |
| missense | 23 | 49 | 33 | 64 |
PlasmoDB Total SNPs: 151
Non-coding: 119 | Synonymous: 14 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 473 | Molecular Weight (kDa): 55.198
UniProt ID(s): Q8IM75
PDB ID(s): None
Isoelectric Point: 6.99
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022742 | Serine aminopeptidase, S33 |
| InterPro | IPR029058 | Alpha/Beta hydrolase fold |
| PFam | PF12146 | Serine aminopeptidase, S33 |
| Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27373432 | A Plasmodium falciparum S33 proline aminopeptidase is associated with changes inerythrocyte deformability. | da Silva FL, Dixon MW, ..., Skinner-Adams TS | 10.1016/j.exppara.2016.06.013 |
| 27795395 | Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection | Spillman NJ, Dalmia VK, Goldberg DE | 10.1128/mBio.01538-16 |