About Gene List

PF3D7_1401400 (ETRAMP14)

Genome location: Pf3D7_14_v3:52,256..54,457(-)

Genome classification: Core

Function and Localization

Product Description: early transcribed membrane protein 14.1

SignalP Peptide: MKVSNILFFFFAIIAVKLVYPGYVAA

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020005 symbiont-containing vacuole membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 4.15 0.03
Trophozoite expressed 1.74 0.31
Schizont expressed 1.62 0.30
Gametocyte expressed 1.07 0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1401400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0524800)

  • Relative Growth Rate: 0.97 ± 0.19
  • Confidence: 4.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q7KQM5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_141182

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 0 0 0
disruptive 0 0 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 113

Non-coding: 102 | Synonymous: 5 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 107 | Molecular Weight (kDa): 11.427

UniProt ID(s): Q7KQM5, Q9NFH2

PDB ID(s): None

Isoelectric Point: 10.22

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006389 Early transcribed membrane protein (ETRAMP)
PFam PF09716 Early transcribed membrane protein (ETRAMP)
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12686607 etramps, a new Plasmodium falciparum gene family coding for developmentallyregulated and highly charged membrane proteins located at the parasite-host cellinterface. Spielmann T, Fergusen DJ, Beck HP 10.1091/mbc.e02-04-0240
23201113 Systematic analysis of natural antibody responses to P. falciparum merozoiteantigens by protein arrays Fan YT, Wang Y, ..., Chen JH 10.1016/j.jprot.2012.11.020