PF3D7_1401600

Genome location: Pf3D7_14_v3:60,100..64,491(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.84	0.65
Trophozoite	expressed	0.27	0.86
Schizont	expressed	2.16	0.30
Gametocyte	expressed	0.69	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1401600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.412 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM73

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=1.23) with 7K3Z (Global RMSD=17.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131931

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 219

Non-coding: 187 | Synonymous: 13 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 478 | Molecular Weight (kDa): 55.827

UniProt ID(s): Q8IM73

PDB ID(s): None

Isoelectric Point: 6.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006526	Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A