PF3D7_1401900

Genome location: Pf3D7_14_v3:73,418..76,793(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0004309	exopolyphosphatase activity
Process	GO:0006797	polyphosphate metabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.16	0.92
Trophozoite	expressed	0.07	0.96
Schizont	expressed	1.44	0.44
Gametocyte	not expressed	1.13	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1401900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.534 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1040000)

Relative Growth Rate: 0.96 ± 0.19
Confidence: 4.69

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1040000)

Modification: Disrupted | RMgm-2914

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM70

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122774

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	22	11	26
disruptive	6	38	23	57
missense	6	37	23	54

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	40	18	27
disruptive	15	88	48	102
missense	14	73	42	73

PlasmoDB Total SNPs: 278

Non-coding: 241 | Synonymous: 23 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 426 | Molecular Weight (kDa): 52.418

UniProt ID(s): Q8IM70

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52047	N/A