Product Description: DHH phosphoesterase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 3.6.1.1 (Inorganic diphosphatase);3.6.1.11 (Exopolyphosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004309 | exopolyphosphatase activity |
| Process | GO:0006798 | polyphosphate catabolic process |
| Process | GO:0006797 | polyphosphate metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.36 | 0.79 |
| Schizont | expressed | 0.04 | 0.98 |
| Gametocyte | not expressed | 0.18 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1402000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.14 | MFS: -3.249 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM69
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q86TP1 | Exopolyphosphatase PRUNE1 | Homo sapiens | OrthoMCL BLAST | DipyridamineCHEMBL348601 |
Ortholog Group (OrthoMCL): OG6_103741
Most Similar Human Ortholog: Q5SZF2
TM-align score: 0.78 | RMSD: 2.75
Seq Identity: 0.12 | Length: 138 / 498
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143363 | prune exopolyphosphatase 1 |
Protein Length: 498 | Molecular Weight (kDa): 59.31
UniProt ID(s): Q8IM69
PDB ID(s): None
Isoelectric Point: 6.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001667 | DDH domain |
| InterPro | IPR004097 | DHHA2 domain |
| InterPro | IPR038763 | DHH phosphoesterase superfamily |
| PFam | PF01368 | DDH domain |
| PFam | PF02833 | DHHA2 domain |
| Superfamily | SSF64182 | DHH phosphoesterase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 35 | 20 | 27 |
| disruptive | 12 | 73 | 44 | 108 |
| missense | 12 | 71 | 42 | 104 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 68 | 15 | 38 |
| disruptive | 22 | 187 | 67 | 139 |
| missense | 18 | 165 | 58 | 108 |
PlasmoDB Total SNPs: 162
Non-coding: 129 | Synonymous: 21 | Nonsynonymous: 12 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |