About Gene List

PF3D7_1402200 (ApiCOX19)

Genome location: Pf3D7_14_v3:84,195..85,840(+)

Genome classification: Core

Function and Localization

Product Description: cytochrome c oxidase subunit ApiCOX19, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005751 mitochondrial respiratory chain complex IV
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.04 0.98
Trophozoite expressed 0.28 0.82
Schizont expressed 0.72 0.58
Gametocyte expressed 0.35 0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1402200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.667 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1039700)

  • Relative Growth Rate: 0.08 ± 0.03
  • Confidence: 8.71

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM67

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146106

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 9 11
disruptive 2 17 10 23
missense 2 17 10 22

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 25 7 15
disruptive 5 29 22 49
missense 5 26 22 37

PlasmoDB Total SNPs: 152

Non-coding: 145 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 188 | Molecular Weight (kDa): 22.116

UniProt ID(s): Q8IM67

PDB ID(s): None

Isoelectric Point: 9.94

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30204084 Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase Seidi A, Muellner-Wong LS, ..., van Dooren GG 10.7554/eLife.38131
34155201 Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. Evers F, Cabrera-Orefice A, ..., Kooij TWA 10.1038/s41467-021-23919-x
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21