Product Description: 26S proteasome regulatory subunit RPN6
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005838 | proteasome regulatory particle |
| Component | GO:0008541 | proteasome regulatory particle, lid subcomplex |
| Function | GO:0004175 | endopeptidase activity |
| Function | GO:0005198 | structural molecule activity |
| Process | GO:0043248 | proteasome assembly |
| Process | GO:0006508 | proteolysis |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.09 | 0.96 |
| Trophozoite | expressed | 0.31 | 0.81 |
| Schizont | expressed | 0.24 | 0.83 |
| Gametocyte | possibly expressed | 0.12 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1402300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.185 | MFS: -2.939 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM66
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101896
Most Similar Human Ortholog: O00231
TM-align score: 0.87 | RMSD: 3.08
Seq Identity: 0.31 | Length: 421 / 666
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108671 | proteasome 26S subunit, non-ATPase 11 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 42 | 18 | 55 |
| disruptive | 27 | 52 | 39 | 74 |
| missense | 9 | 33 | 34 | 55 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 84 | 27 | 57 |
| disruptive | 47 | 120 | 67 | 199 |
| missense | 18 | 87 | 57 | 118 |
PlasmoDB Total SNPs: 208
Non-coding: 124 | Synonymous: 54 | Nonsynonymous: 30 | Stop Codon: 0
Protein Length: 666 | Molecular Weight (kDa): 78.381
UniProt ID(s): Q8IM66
PDB ID(s): None
Isoelectric Point: 6.17
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000717 | Proteasome component (PCI) domain |
| InterPro | IPR036390 | Winged helix DNA-binding domain superfamily |
| InterPro | IPR040773 | 26S proteasome regulatory subunit Rpn6, N-terminal |
| PFam | PF01399 | Proteasome component (PCI) domain |
| PFam | PF18055 | 26S proteasome regulatory subunit Rpn6, N-terminal |
| Superfamily | SSF46785 | Winged helix DNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21368162 | Asparagine repeat function in a Plasmodium falciparum protein assessed via aregulatable fluorescent affinity tag. | Muralidharan V, Oksman A, ..., Goldberg DE | 10.1073/pnas.1018449108 |