PF3D7_1402400

Genome location: Pf3D7_14_v3:89,265..91,389(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071011	precatalytic spliceosome
Function	GO:0003723	RNA binding
Process	GO:0008380	RNA splicing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.29	0.86
Trophozoite	possibly expressed	0.66	0.63
Schizont	expressed	0.31	0.81
Gametocyte	possibly expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1402400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -2.885 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1039500)

Relative Growth Rate: 0.07 ± 0.17
Confidence: 4.95

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM65

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106550

Most Similar Human Ortholog: O75554

TM-align score: 0.27 | RMSD: 4.19

Seq Identity: 0.23 | Length: 117 / 490

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000120688	WW domain binding protein 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	25	11	39
disruptive	14	87	43	101
missense	12	71	39	91

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	56	17	40
disruptive	26	199	86	182
missense	18	157	71	118

PlasmoDB Total SNPs: 112

Non-coding: 78 | Synonymous: 23 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 490 | Molecular Weight (kDa): 58.98

UniProt ID(s): Q8IM65

PDB ID(s): None

Isoelectric Point: 8.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger
InterPro	IPR040023	WW domain-binding protein 4
PFam	N/A	N/A
Superfamily	N/A	N/A