Product Description: ribosomal protein S27a, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0031386 | protein tag |
| Function | GO:0003735 | structural constituent of ribosome |
| Function | GO:0031625 | ubiquitin protein ligase binding |
| Process | GO:0019941 | modification-dependent protein catabolic process |
| Process | GO:0016567 | protein ubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.97 | 0.30 |
| Trophozoite | expressed | 2.31 | 0.18 |
| Schizont | expressed | 0.46 | 0.74 |
| Gametocyte | possibly expressed | 1.62 | 0.28 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1402500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.14 | MFS: -2.905 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1039400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM64
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q15843 | NEDD8 | OrthoDB | Pevonedistat |
Ortholog Group (OrthoMCL): OG6_101107
Most Similar Human Ortholog: J3QTR3
TM-align score: 0.58 | RMSD: 2.68
Seq Identity: 0.32 | Length: 74 / 149
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143947 | ribosomal protein S27a |
| ENSG00000231767 | ribosomal protein S27a pseudogene 5 |
Protein Length: 149 | Molecular Weight (kDa): 17.4
UniProt ID(s): Q8IM64
PDB ID(s): None
Isoelectric Point: 10.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000626 | Ubiquitin-like domain |
| InterPro | IPR002906 | Ribosomal protein S27a |
| InterPro | IPR011332 | Zinc-binding ribosomal protein |
| InterPro | IPR029071 | Ubiquitin-like domain superfamily |
| PFam | PF00240 | Ubiquitin-like domain |
| PFam | PF01599 | Ribosomal protein S27a |
| Superfamily | SSF54236 | Ubiquitin-like domain superfamily |
| Superfamily | SSF57829 | Zinc-binding ribosomal protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 144
Non-coding: 140 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |