PF3D7_1402700 (SR140)

Genome location: Pf3D7_14_v3:94,596..99,118(-)

Genome classification: Core

Function and Localization

Product Description: U2 snRNP-associated SURP motif-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1402700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.057 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1039300)

• Relative Growth Rate: 0.39 ± 0.09
• Confidence: 6.31

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1039300)

Modification: Disrupted | RMgm-2909

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A0W9

"Best" AlphaFill ligand hit: ADE (adenine, Local RMSD=3.78) with 3LQV (Global RMSD=8.56)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102628

Most Similar Human Ortholog: U3KPT1

TM-align score: 0.34 | RMSD: 5.53

Seq Identity: 0.08 | Length: 87 / 653

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 401

Non-coding: 349 | Synonymous: 37 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 653 | Molecular Weight (kDa): 77.776

UniProt ID(s): A0A144A0W9

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations: