About Gene List

PF3D7_1402800

Genome location: Pf3D7_14_v3:100,564..106,014(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000123 histone acetyltransferase complex
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.62 0.72
Trophozoite possibly expressed 1.01 0.50
Schizont expressed 1.24 0.42
Gametocyte possibly expressed 0.73 0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1402800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.961 | MFS: -1.778 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM62

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533707

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 25 90 48 98
disruptive 160 321 147 336
missense 79 190 118 232

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 42 172 62 102
disruptive 265 625 237 445
missense 122 400 161 219

PlasmoDB Total SNPs: 460

Non-coding: 129 | Synonymous: 165 | Nonsynonymous: 166 | Stop Codon: 0

Protein Information

Protein Length: 1511 | Molecular Weight (kDa): 180.78

UniProt ID(s): Q8IM62

PDB ID(s): None

Isoelectric Point: 8.93

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
31728527 Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. Hoeijmakers WAM, Miao J, ..., Bartfai R 10.1093/nar/gkz1044
34403450 A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum. Miao J, Wang C, ..., Cui L 10.1371/journal.ppat.1009351