PF3D7_1403000

Genome location: Pf3D7_14_v3:110,031..112,645(+)

Genome classification: Core

Function and Localization

Product Description: radial spoke protein 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.83	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1403000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.968 | MFS: -2.028 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM61

"Best" AlphaFill ligand hit: IZA (2-(1,1-dimethylethyl)9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Local RMSD=21.38) with 3EYH (Global RMSD=31.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532861

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	19	15	26
disruptive	24	71	53	115
missense	18	65	45	101

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	42	20	25
disruptive	39	188	86	124
missense	25	155	68	87

PlasmoDB Total SNPs: 286

Non-coding: 195 | Synonymous: 49 | Nonsynonymous: 41 | Stop Codon: 1

Protein Information

Protein Length: 453 | Molecular Weight (kDa): 54.382

UniProt ID(s): Q8IM61

PDB ID(s): None

Isoelectric Point: 9.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009290	Radial spoke 3
PFam	PF06098	Radial spoke 3
Superfamily	N/A	N/A