Product Description: condensin complex subunit 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000779 | condensed chromosome, centromeric region |
| Component | GO:0000796 | condensin complex |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0042393 | histone binding |
| Process | GO:0051304 | chromosome separation |
| Process | GO:0010032 | meiotic chromosome condensation |
| Process | GO:0007076 | mitotic chromosome condensation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.13 | 0.94 |
| Trophozoite | no data | 0.91 | 0.52 |
| Schizont | no data | 0.84 | 0.54 |
| Gametocyte | no data | 1.15 | 0.43 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1403100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.36 | MFS: -2.538 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3H2
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.49) with 6JWQ (Global RMSD=15.12)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102273
Most Similar Human Ortholog: E7EN77
TM-align score: 0.58 | RMSD: 6.15
Seq Identity: 0.12 | Length: 673 / 1955
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000010292 | non-SMC condensin I complex subunit D2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 121 | 69 | 138 |
| disruptive | 110 | 284 | 170 | 395 |
| missense | 59 | 213 | 140 | 319 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 54 | 236 | 88 | 146 |
| disruptive | 169 | 601 | 252 | 526 |
| missense | 95 | 444 | 201 | 403 |
PlasmoDB Total SNPs: 323
Non-coding: 77 | Synonymous: 147 | Nonsynonymous: 97 | Stop Codon: 2
Protein Length: 1955 | Molecular Weight (kDa): 229.535
UniProt ID(s): C6S3H2
PDB ID(s): None
Isoelectric Point: 6.4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007673 | Condensin subunit 1 |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR026971 | Condensin subunit 1/Condensin-2 complex subunit D3 |
| InterPro | IPR032682 | Condensin complex subunit 1, C-terminal |
| PFam | PF12717 | Condensin complex subunit 1, C-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32049018 | Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. | Pandey R, Abel S, ..., Tewari R | 10.1016/j.celrep.2020.01.033 |