PF3D7_1403200

Genome location: Pf3D7_14_v3:119,995..121,405(-)

Genome classification: Core

Function and Localization

Product Description: EGF domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.01	0.99
Gametocyte	expressed	1.19	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1403200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.113 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3H3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533099

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	11	20
disruptive	16	42	26	41
missense	16	40	26	38

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	20	16	20
disruptive	25	81	39	64
missense	22	75	35	46

PlasmoDB Total SNPs: 68

Non-coding: 52 | Synonymous: 6 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 291 | Molecular Weight (kDa): 34.706

UniProt ID(s): C6S3H3

PDB ID(s): None

Isoelectric Point: 8.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009030	Growth factor receptor cysteine-rich domain superfamily
InterPro	IPR024731	EGF domain
PFam	PF12947	EGF domain
Superfamily	SSF57184	Growth factor receptor cysteine-rich domain superfamily