About Gene List

PF3D7_1403300

Genome location: Pf3D7_14_v3:121,855..125,340(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite expressed 0.09 0.94
Schizont expressed 0.05 0.97
Gametocyte expressed 0.46 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1403300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.856 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1038700)

  • Relative Growth Rate: 1.08 ± 0.14
  • Confidence: 5.30

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1038700)

Modification: Disrupted | RMgm-2907

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM60

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533002

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 51 37 94
disruptive 29 163 85 237
missense 24 157 82 221

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 115 49 83
disruptive 66 368 167 308
missense 44 319 146 244

PlasmoDB Total SNPs: 70

Non-coding: 0 | Synonymous: 38 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 1161 | Molecular Weight (kDa): 142.708

UniProt ID(s): Q8IM60

PDB ID(s): None

Isoelectric Point: 9.97

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
InterPro IPR019734 Tetratricopeptide repeat
PFam N/A N/A
Superfamily SSF48452 Tetratricopeptide-like helical domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104