Product Description: dynein regulatory complex protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005930 | axoneme |
| Process | GO:0070286 | axonemal dynein complex assembly |
| Process | GO:0060285 | cilium-dependent cell motility |
| Process | GO:0003352 | regulation of cilium movement |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.98 |
| Trophozoite | not expressed | 0.60 | 0.67 |
| Schizont | not expressed | 0.36 | 0.79 |
| Gametocyte | not expressed | 1.02 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1403400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.61 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A137
"Best" AlphaFill ligand hit: DEQ (dequadin, Local RMSD=0.04) with 3BR2 (Global RMSD=33.55)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104900
Most Similar Human Ortholog: F8WE02
TM-align score: 0.59 | RMSD: 2.46
Seq Identity: 0.12 | Length: 85 / 647
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000157856 | dynein regulatory complex subunit 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 29 | 24 | 43 |
| disruptive | 16 | 77 | 46 | 85 |
| missense | 16 | 76 | 45 | 81 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 63 | 28 | 40 |
| disruptive | 33 | 177 | 65 | 167 |
| missense | 30 | 159 | 53 | 119 |
PlasmoDB Total SNPs: 299
Non-coding: 265 | Synonymous: 16 | Nonsynonymous: 18 | Stop Codon: 0
Protein Length: 647 | Molecular Weight (kDa): 78.837
UniProt ID(s): A0A144A137
PDB ID(s): None
Isoelectric Point: 9.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR029440 | Dynein regulatory complex protein 1, C-terminal |
| InterPro | IPR039750 | Dynein regulatory complex protein |
| PFam | PF14775 | Dynein regulatory complex protein 1, C-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |