PF3D7_1403500

Genome location: Pf3D7_14_v3:130,022..132,234(-)

Genome classification: Core

Function and Localization

Product Description: dynein light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.03	0.98
Schizont	no data	0.11	0.92
Gametocyte	no data	0.39	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1403500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.192 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1038500)

Relative Growth Rate: 1.08 ± 0.13
Confidence: 5.49

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1038500)

Modification: Disrupted | RMgm-2906

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3H4

"Best" AlphaFill ligand hit: AE3 (2-(2-ethoxyethoxy)ethanol, Local RMSD=0.11) with 6FQX (Global RMSD=15.08)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103386

Most Similar Human Ortholog: A0A499FIY3

TM-align score: 0.37 | RMSD: 5.25

Seq Identity: 0.09 | Length: 154 / 270

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000163879	dynein axonemal light intermediate chain 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	21	10	21
disruptive	3	19	16	45
missense	3	19	16	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	32	11	25
disruptive	6	60	41	68
missense	6	53	37	54

PlasmoDB Total SNPs: 157

Non-coding: 144 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 270 | Molecular Weight (kDa): 32.467

UniProt ID(s): C6S3H4

PDB ID(s): None

Isoelectric Point: 5.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019347	Axonemal dynein light chain
PFam	PF10211	Axonemal dynein light chain
Superfamily	N/A	N/A