About Gene List

PF3D7_1403600 (SEL1)

Genome location: Pf3D7_14_v3:131,925..133,539(+)

Genome classification: Core

Function and Localization

Product Description: selenoprotein 1

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005783 endoplasmic reticulum
Process GO:0045454 cell redox homeostasis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite possibly expressed 0.07 0.95
Schizont expressed 0.26 0.82
Gametocyte expressed 0.15 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1403600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.523 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533451

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 5 3 7
disruptive 1 14 8 24
missense 1 14 7 23

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 10 2 12
disruptive 5 33 14 30
missense 4 30 11 25

PlasmoDB Total SNPs: 88

Non-coding: 85 | Synonymous: 0 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 116 | Molecular Weight (kDa): 13.374

UniProt ID(s): Q8IM58

PDB ID(s): None

Isoelectric Point: 10.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16428245 The Plasmodium selenoproteome. Lobanov AV, Delgado C, ..., Gladyshev VN 10.1093/nar/gkj450
22229886 Insight into the selenoproteome of the malaria parasite Plasmodium falciparum. Roseler A, Prieto JH, ..., Becker K 10.1089/ars.2011.4276