Product Description: serine/threonine protein phosphatase CPPED1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase);3.1.3.2 (Acid phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.23 | 0.86 |
| Schizont | expressed | 0.02 | 0.98 |
| Gametocyte | expressed | 0.19 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1403900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.172 | MFS: -2.825 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM55
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_107606
Most Similar Human Ortholog: Q9BRF8
TM-align score: 0.90 | RMSD: 1.56
Seq Identity: 0.31 | Length: 282 / 298
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103381 | calcineurin like phosphoesterase domain containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 10 | 19 |
| disruptive | 2 | 9 | 9 | 26 |
| missense | 2 | 9 | 9 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 30 | 16 | 24 |
| disruptive | 7 | 27 | 30 | 70 |
| missense | 4 | 21 | 25 | 62 |
PlasmoDB Total SNPs: 131
Non-coding: 126 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 298 | Molecular Weight (kDa): 35.219
UniProt ID(s): Q8IM55
PDB ID(s): None
Isoelectric Point: 6.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
| PFam | PF00149 | Calcineurin-like phosphoesterase domain, ApaH type |
| Superfamily | SSF56300 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34009729 | Human CPPED1 belongs to calcineurin-like metallophosphoesterase superfamily anddephosphorylates PI3K-AKT pathway component PAK4 | Haapalainen AM, Daddali R, Hallman M, Ramet M | 10.1111/jcmm.16607 |